© 2017 Fujinaga laboratory

 

論文業績 (2015年以降)

原著

Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption.

Sho Amatsu, Takuhiro Matsumura, Masahiro Yutani, Yukako Fujinaga

Microbiol Immunol. 2018 Feb;62(2):80-89. doi: 10.1111/1348-0421.12565.

Translocation and dissemination of botulinum neurotoxin from the intestinal tract.

Yukako Fujinaga, Michel R Popoff

Toxicon. 2018 Jun 1;147:13-18. doi: 10.1016/j.toxicon.2017.10.020. Epub 2017 Oct 24.

A simple and robust method for culturing human-induced pluripotent stem cells in an undifferentiated state using botulinum hemagglutinin.

Mee-Hae H Kim, Yoshifumi Matsubara, Yukako Fujinaga, Masahiro Kino-Oka

Biotechnol J. 2018 Feb;13(2). doi: 10.1002/biot.201700384. Epub 2017 Oct 30.

Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies.

Mee-Hae H Kim, Yo Sugawara, Yukako Fujinaga, Masahiro Kino-Oka

Sci Rep. 2017 Mar 7;7(1):93. doi: 10.1038/s41598-017-00083-1.

論文業績(2013年~2015年)

2015年
原著
Sugawara Y., Iwamori M., Matsumura T., Yutani M., Amatu S., Fujinaga Y.

Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3.

FEBS J 282: 3334-47 (2015)

Matsumura T., Sugawara Y., Yutani M., Amatsu S., Yagita H., Kohda T., Fukuoka S., Nakamura Y., Fukuda S., Hase K., Ohno H., Fujinaga Y.

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity.

Nature Communications 6, 6255: (2015)

総説
松村拓大、藤永由佳子

ボツリヌス神経毒素複合体の体内侵入機構 
臨床免疫・アレルギー科 64巻1号、(65-69) 2015年7月

藤永由佳子、松村拓大

腸管 M 細胞を介したボツリヌス毒素の侵入機構 
感染 炎症 免疫 45巻、(175-184)2015年

2014年
原著
Sugawara Y., Yutani M., Amatsu S., Matsumura T., Fujinaga Y.

Functional dissection of the Clostridium botulinum type B hemagglutinin complex: Identification of the carbohydrate and E-cadherin binding sites.

PLOS ONE 9; e111170: 1-9 (2014)

2013年
原著
Nakayama T., Takeuchi D., Matsumura T., Akeda Y., Fujinaga Y., Oishi K.

Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections.

Microbial Pathogenesis 65: 14-20 (2013)

Amatsu S., Sugawara Y., Matsumura T., Kitadokoro K., Fujinaga Y.

Cystal structure of Clostridium botulinum whole hemagglutinin reveals a huge triskelion-shaped molecular complex.

J. Biol. Chem. 288: 35617- 35625 (2013)

総説
藤永由佳子

重篤な食中毒を引き起こす細菌毒素の研究の最前線 志賀毒素(ベロ毒素)とボツリヌス毒素

ファルマシア 49巻、764-768 (2013)

著書
Fujinaga Y., Sugawara Y., Matsumura T.

Uptake of botulinum neurotoxin in the intestine.

In Rummel A. and Binz T. (eds.), Botulinum Neurotoxins, Springer-Verlag, 45-59 (2013)

[Curr. Top. Microbiol. Immunol. 364:45-59 (2013)]